Histone Mutants Separate R Loop Formation from Genome Instability Induction
نویسندگان
چکیده
منابع مشابه
R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
Genome instability via RNA:DNA hybrid-mediated R loops has been observed in mutants involved in various aspects of transcription and RNA processing. The prevalence of this mechanism among essential chromosome instability (CIN) genes remains unclear. In a secondary screen for increased Rad52 foci in CIN mutants, representing ∼25% of essential genes, we identified seven essential subunits of the ...
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1 Terry Fox Laboratory, BC Cancer Agency, Vancouver BC, Canada V5Z 1L3 2 Centre for Molecular Medicine and Therapeutics, Vancouver BC, Canada V5Z 4H4 3 Genome Stability Laboratory, CHU de Québec Research Center, HDQ Pavilion, Oncology Axis, 9 McMahon, Québec City, QC G1R 2J6, Canada 4 Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Q...
متن کاملPIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
Saccharomyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3. Rrm3 promotes DNA replication past stable protein complexes at tRNA genes (tDNAs). We identify a new role for the Pif1 helicase: promotion of replication and suppression of DNA damage at tDNAs. Pif1 binds multiple tDNAs, and this binding is higher in rrm3Δ cells. Accumulation of replication intermediates and DNA dama...
متن کاملTranscription-coupled nucleotide excision repair factors promote R-loop-induced genome instability.
R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin. Intriguingly, changes in R-loop dynamics have also been associated with DNA damage accumulation and genome instability; however, the mechanisms underlying R-loop-induced DNA damage remain unknown. Here we demonstrate in human c...
متن کاملR - loop - mediated genomic instability is caused by impairment of
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2017
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2017.05.014